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To assess no matter whether two monoclonal antibodies synergize in a cocktail to neutralize SARS-CoV-two, we utilized a previously reported approach to quantify synergy11. To evaluate the significance of the helpful effect from combining monoclonal antibodies, the observed mixture responses (dose–response matrix) had been compared with the expected responses calculated by indicates of synergy-scoring models11. Virus neutralization was measured in a conventional FRNT assay using wild-form SARS-CoV-two and Vero E6 cell-culture monolayers. The individual monoclonal antibodies COV and COV had been mixed at unique concentrations to assess the neutralizing activity of distinctive ratios of monoclonal antibodies in the cocktail. The...